Seven days following peroral infection with 109 CFU C. jejuni strain 81–176 on two consecutive days (i.e., days 0 and 1), however, Nod2 was down-regulated in the large intestines of both WT and IL-10−/− mice (p < 0.001 and p < 0.05, respectively; Figure 1). This evidence concerns the gene IL10 and infection.