IL10 and ulcer disease: Following depletion of the intestinal microbiota by broad-spectrum antibiotic treatment, however, secondary abiotic (i.e., gnotobiotic) IL-10−/− mice can be stably infected by the pathogen with high loads and develop non-selflimiting ulcerative enterocolitis with bloody diarrhea, thus displaying key features of campylobacteriosis in immunocompromised patients (Haag et al., 2012; Heimesaat et al., 2014a,c; Fiebiger et al., 2016).