Following a much longer course of broad-spectrum antibiotic treatment (i.e., 8 weeks) with a different, quintuple antibiotic regimen, secondary abiotic IL-10−/− mice develop severe ulcerative enterocolitis with bloody diarrhea that is not self-limiting and requires necrospsy until day 7 p.i. (Haag et al., 2012; Heimesaat et al., 2014a,c; Fiebiger et al., 2016). This evidence concerns the gene IL10 and ulcer disease.