Tumor-associated gain-of-function mutant p53 proteins have been identified (Brosh and Rotter, 2009) which may activate different metabolic pathways, e.g., the mevalonate pathway and hence lipid metabolism, glucose uptake with subsequent enhanced glycolysis or loss of the ability to block G6PDH activity, thereby activating the PPP (Jiang et al., 2011). Here, TP53 is linked to neoplasm.