Our recent research found that deletion of protein tyrosine phosphatase 1B (PTP1B) within the myeloid cell lineage led to protection against high-fat diet (HFD)-induced and bacterial toxin (lipopolysaccharide LPS)-induced inflammation and hyperinsulinemia, due to increased anti-inflammatory IL-10 and decreased pro-inflammatory TNFα cytokine secretion in vivo[13]. This evidence concerns the gene PTPN1 and Hyperinsulinemia.