Since we initially hypothesized that increased IL-10 levels associated with myeloid-PTP1B deficiency may create an anti-inflammatory environment and lead to protection against atherosclerosis development, we next determined circulating levels of IL-10 in ApoE−/−/LysM-PTP1B and ApoE−/− controls on chow and HFD. This evidence concerns the gene APOE and atherosclerosis.