Most early interest focused on eotaxins (CCL11, CCL24, and CCL26) and their receptor CCR3 because of their role in promoting tissue eosinophilia in a wide variety of eosinophilic disorders, including asthma, eosinophilic gastrointestinal (GI) disease, eosinophilic skin diseases, and most recently eosinophil trafficking to the heart in a murine model of myocarditis44. This evidence concerns the gene CCR3 and Increased total eosinophil count.