ATF2 and cancer: In summary, chronically induced accumulation of Chk1, reinforced binding of activated Chk1, GCN5, Ac-H3K9, PCAF, ATF2, and c-Jun, restrained accumulation of p-H3T11, and induced binding of p300/CBP on chromatin could induce the expression of genes known to cause uncontrolled proliferation and undetected DNA damage through DNA damage response bypass, which are hallmarks of cancer.