In summary, chronically induced accumulation of Chk1, reinforced binding of activated Chk1, GCN5, Ac-H3K9, PCAF, ATF2, and c-Jun, restrained accumulation of p-H3T11, and induced binding of p300/CBP on chromatin could induce the expression of genes known to cause uncontrolled proliferation and undetected DNA damage through DNA damage response bypass, which are hallmarks of cancer. The gene discussed is EP300; the disease is cancer.