NOS2 and amyotrophic lateral sclerosis: Consistent with this information, increased levels of SNO-PDI have been detected in the brains of patients with PD, AD, and amyotrophic lateral sclerosis (ALS) [135, 136] and in response to iNOS activation in animal models of ALS [137] or in response to mitochondrial toxins, such as rotenone and MPTP, in cellular models [110, 135].