For example, antago-miR mediated inactivation of miR-25, which is selectively upregulated in cardiomyocytes from TAC-overloaded hearts and targets mRNAs such as sarcoplasmic reticulum calcium ATPase 2a (SERCA2a) and inositol-3′-phosphate receptor-1 (IP3R1), improves calcium reuptake and myocardial contractility during HF [175]. This evidence concerns the gene ITPR1 and hydrops fetalis.