CASP3 and cerebrovascular disorder: A significant increase of both cleaved caspase-3 and c-Jun proteins expressions was observed in the brain of JD-fed SHRSP but not in JD-fed SHRSR (Figures 3(a) and 3(b)), pointing to a clear evidence that apoptosis and necrosis were already detectable at this early stage of cerebrovascular disease [13, 14].