Clinical data also revealed that patients with new-onset RA had lesser IL-10-competent B cells, comprising CD19+CD5+CD1d+ cells and CD19+ TIM1+ cells, than healthy controls and that this decrease was positively correlated with the number of CD4+CD25+FoxP3+ Treg cells in peripheral blood [37]. The gene discussed is CD1D; the disease is rheumatoid arthritis.