Meanwhile, the hypermethylation at the MLH1 promoter has been well-known in colon cancers (Kane et al., 1997; Cunningham et al., 1998; Herman et al., 1998; Simpkins et al., 1999; Toyota et al., 1999; Nakagawa et al., 2001; Wallner et al., 2006; Weisenberger et al., 2006; Ahlquist et al., 2008; Hinoue et al., 2012; Li et al., 2013). The gene discussed is MLH1; the disease is colonic neoplasm.