MLH1 and cancer: In the comparison of the colon vs. the other cancer groups, chr5:38557143 (FDR = 9.25 × 10-13) and chr3:37034084 (FDR = 2.32 × 10-11) at the LIFR and MLH1 gene promoters, respectively, were found to be differentially methylated; both CpGs were consistently hypermethylated in the colon cancer cell lines while hypomethylated in the other cell lines (Figure 3B).