In stroke-prone spontaneously hypertensive rats were found downregulation of VEGF (26, 27), VEGFR-1 (Flt-1), and VEGFR-2 (Flk-1) receptors, endothelial nitric oxide synthase and the phosphorylated Akt in frontal cortex (26, 27). The gene discussed is FLT1; the disease is Stroke.