The link of α-synuclein with EIF4G1 presumably is involved in pathological alterations in PD and other neurodegenerative disease, since this translation initiation factor is linked to both PD (Chartier-Harlin et al., 2011) and Lewy body dementia (Fujioka et al., 2013). This evidence concerns the gene EIF4G1 and Parkinson disease.