Tumor suppression through caloric restriction occurs through induction of apoptosis in cancer cells.(23) To confirm this mechanisms, we measured mRNA levels of the anti-apoptotic gene Bcl-2 and pro-apoptotic gene Bax.(24–26) In caloric restriction, mRNA for Bax increased and mRNA for Bcl-2 decreased in cancer cells. The gene discussed is BCL2; the disease is neoplasm.