β-carotene induces CSC differentiation in neuroblastomas through ERK activation and down-regulation of Drosophila delta-like 1 homolog.(41) One of the apocarotenoids, crocetinic acid, a compound from saffron, suppresses cell growth in human pancreatic CSCs through inhibiting Sonic Hedgehog and EGFR.(42). The gene discussed is EGFR; the disease is neuroblastoma.