Previously, we demonstrated that sesamol, a natural polar lipid as well as FuOH, suppressed COX-2 transcriptional activity in CRC cells and the mRNA expression in the intestinal polyp part in ApcMin/+ mice.(36) The COX-2 transactivation could also play some roles in FuOH-induced apoptosis in the cells of Csp. This evidence concerns the gene PTGS2 and colorectal carcinoma.