There is also a marked loss of nervous cells in the cerebral cortex.(52) In recent years, oxidative stress and neuroinflammation have been reported to be involved in AD.(1,5) To date, reports have centered on the involvement of oxidative stress in brain parenchyma.(1,51,53) The accumulation of Aβ protein is strongly associated with the failure of Aβ clearance that is closely related to the pathogenesis of AD.(5) It is known that low-density lipoprotein receptor-related protein 1 (LRP1) is involved in Aβ protein elimination. Here, LRP1 is linked to Alzheimer disease.