Our previous studies have revealed that miR-199a-5p and miR-199a-3p form gene regulation networks in human epithelial tumour cell lines by suppressing their common target, Brm, a catalytic subunit of the SWI/SNF complex, and further that these tumour cell lines tend to fall into either of two steady states: miR-199a(−)/Brm(+) and miR-199a(+)/Brm(−) through a miR-199a/Brm/EGR1 axis8, 9. The gene discussed is SMARCA1; the disease is neoplasm.