Hemizygous deficiency in Klf2+/−mice on apolipoprotein E deficient (ApoE−/−) background (Klf2+/−; ApoE−/−) exhibited increased diet-induced atherosclerosis versus wild-type ApoE deficient mice (Klf2+/+; ApoE−/−)2. This evidence concerns the gene APOE and atherosclerosis.