GRN and autosomal dominant disease: The identification of mutations responsible of autosomal dominant inherited disorder, namely Microtuble Associated Protein Tau (MAPT), Granulin (GRN) and chromosome 9 open reading frame 72 (C9orf72) mutations, has further elucidated the molecular pathways involved in brain depositions of either Tau or TAR DNA-binding protein 43 (TDP43) inclusions5.