MAPT and frontotemporal dementia: Several evidences have claimed for a possible role of AMPARs in FTD pathogenesis: (i) the hyperexcitability of AMPARs contribute to neurodegeneration29, (ii) in animal model of FTD, the social deficits were accompanied by a change of AMPAR composition29; (iii) frontal cortex and hiPSCs of bvFTD patients showed changes of AMPARs30; and (iv) physiological release of Tau protein is mediated by AMPARs14.