Surprisingly, data retrieved from large‐scale databases of human tissue samples (TCGA; and The Atlas of noncoding RNAs in Cancer, TANRIC) show homogeneous expression of PCA3 only in prostate cancer, but not in other tumor types, including those in which PRUNE2 loss‐of‐function events have been reported, that is, Merkel cell carcinoma, neuroblastoma, glioblastoma, and parathyroid carcinoma. The gene discussed is PRUNE2; the disease is prostate cancer.