In prostate cancer patients, decreased levels of PRUNE2 are indicative of poor prognosis, as this is associated with metastatic disease (National Center for Biotechnology Information, Gene Expression Omnibus, NCBI GEO, profile 34856174; n = 171) and a high Gleason score (The Cancer Genome Atlas, TCGA; n = 497). This evidence concerns the gene PRUNE2 and prostate cancer.