The Crigler‐Najjar syndrome type I (CNSI) is a rare monogenic pediatric disease (0.6–1 cases per 106 live births) caused by a deficiency in the liver‐specific uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1), resulting in severe unconjugated hyperbilirubinemia since birth, with lifelong risk of permanent neurological damage, kernicterus, and death (Crigler & Najjar, 1952; Huang et al, 1970). Here, UGT1A1 is linked to Hyperbilirubinemia.