In the Natriuretic Peptides Studies Collaboration, a large collaborative individual-participant-data meta-analysis, NT-proBNP demonstrated associations with CVD (RR: 1.76; 95% CI: 1.56 to 1.98) and CHD (RR: 1.67; 95% CI: 1.45 to 1.93) that were of similar magnitude to those observed in PROSPER for hs-cTnT (48). The gene discussed is NPPB; the disease is coronary artery disorder.