Because lymphocytes contain α7nAChRs and abundant CHRFAM7A and the Aβ42-α7nAChR complexes are more abundant in AD [7, 35], we assessed whether the Aβ42-α7-like nAChR complex levels are higher in the membranes of lymphocytes from AD and MCI patients and whether the abundance of Aβ42-α7-like nAChR complexes correlate with the APOE genotypes, especially the APOE ε4. This evidence concerns the gene CHRNA7 and Alzheimer disease.