Using the percentage increase by the addition of plasma, our data indicate that apoE4 promotes the Aβ42-α7nAChR association: the levels of Aβ42-α7nAChR complexes progressively increased as the number of APOE ε4 alleles increased in MCI and AD cases (Fig. 6a and c). The gene discussed is CHRNA7; the disease is Alzheimer disease.