Our data show that the Aβ42-α7nAChR complexes were more abundant when incubated with plasma from subjects with MCI (increased by 44.7 ± 6.7%) and AD (increased by 99.5 ± 3.6%) compared to plasma from controls (increased by 13.5 ± 4.1%) regardless of APOE genotypes in visit 1 (Fig. 6a and b). The gene discussed is CHRNA7; the disease is Alzheimer disease.