Since APOE ε4 is a prominent late-onset AD risk factor, the Aβ42-α7nAChR complexes in lymphocytes derived from patients enrolled in the CL2-NEURO-003 study (ROSAS cohort) [34] with diverse APOE genotypes who gave blood samples at two time-points at least 1 year apart were examined to determine whether Aβ42-α7nAChR complexes in lymphocytes are correlated with APOE genotype (APOE ε4 specifically). Here, CHRNA7 is linked to Alzheimer disease.