POU2F2 and neoplasm: Using DNA methylation and expression data from 333 TCGA tumor samples, we calculated the correlation between the expression of six TF hub genes that are significantly altered by SVs (ERG, TP53, POU2F2, SPI1, CREB3LI, and ERF) and average DNA methylation (β values) at differentially methylated probes within specific TF motifs.