The TF hubs that show differential expression due to SVs are ERG, TP53, POU2F2, CREB3LI, and ERF. Out of these, ERG and TP53 are known PCa genes and we propose that POU2F2, CREB3L1, and ERF can also play an important role in prostate tumorigenesis. Here, TF is linked to male reproductive organ cancer.