Using DNA methylation and expression data from 333 TCGA tumor samples, we calculated the correlation between the expression of six TF hub genes that are significantly altered by SVs (ERG, TP53, POU2F2, SPI1, CREB3LI, and ERF) and average DNA methylation (β values) at differentially methylated probes within specific TF motifs. This evidence concerns the gene SPI1 and neoplasm.