TF and posterior cortical atrophy: Using our novel computational approach, we first determined prostate-specific TF hubs and then analyzed WGS data from 188 primary PCa samples from the International Cancer Genome Consortium (ICGC) and other published studies [5, 9, 47] along with DNA methylation data from 333 samples from TCGA [3] to identify genetic and epigenetic alterations that alter hub expression and cause large-scale network changes, potentially driving the transformation of normal cells to a tumorigenic state.