PTPN11 and hepatocellular carcinoma: As shown in Fig. 7a-e, miR-500a-3p expression level in HCC tissues was negatively associated with expression levels of SOCS2 (r = −0.756, P < 0.05), SOCS4 (r = −0.721, P < 0.05), and PTPN11 (r = −0.785, P < 0.05).