LGMD type 2E (LGMD2E), with a mutation in the beta-sarcoglycan (SGCB) gene, represents a severe form of LGMD [22, 23], often associated with cardiomyopathy and abnormalities in the vasculature [23–25]. The gene discussed is SGCB; the disease is autosomal recessive limb-girdle muscular dystrophy type 2E.