The amount of the end products (docosahexaenoic acid in the n-3 and arachidonic acid in the n-6 family) did not show any elevation in response to isolated hypercholesterolemia due to decreased expression of FADS1 and FADS2 (i.e. Δ5- and Δ6-desaturases) limiting the synthesis of docosahexaenoic acid and arachidonic acid (Figs. 8 and 9). The gene discussed is FADS1; the disease is familial hypercholesterolemia.