This overall mutation frequency was similar in each treatment arm (30% in TCL arm [three samples], 31.3% in TCH arm [ten samples], and 31.3% in TCHL arm [ten samples]) and was not influenced by ER status (27.6% in ER-negative tumours, 33.3% in ER-positive tumours) or PR status (32.6% in PR-negative tumours, 29% in PR-positive tumours) (Table 2). Specific mutations identified are detailed in Additional file 2. The gene discussed is PGR; the disease is neoplasm.