Chao et al. [46] reported reexpression of E-cadherin in distant metastases arising in organs such as the liver, brain, and lung from primary breast tumors that were E-cadherin-low or E-cadherin-negative, and they suggested that the reexpression of E-cadherin in metastases was mediated by E-cadherin promoter demethylation influenced by the microenvironment of the metastatic site. The gene discussed is CDH1; the disease is breast neoplasm.