In other studies, Saha et al. [103] showed reexpression of E-cadherin in bone metastases that originated from E-cadherin-negative, poorly differentiated primary breast carcinoma, and Chao et al. [46] reported the reexpression of E-cadherin at distant metastases arising from E-cadherin-low or E-cadherin-negative primary tumors. The gene discussed is CDH1; the disease is breast carcinoma.