As previously reported [66], we have shown that the MDA-MB-468 human breast cancer cell line displays significant EMP in vivo, dynamically switching on a mesenchymal phenotype in the primary tumor either at the periphery or in response to HPX (EMT) but exhibiting a predominantly epithelial phenotype in the xenograft center and at the secondary sites in local LNs and the lung. The gene discussed is HPX; the disease is neoplasm.