CDH1 and neoplasm: E-cadherin expression may be advantageous for the formation of these lung metastases because we observed a trend toward a higher number of micrometastases in this organ in the mice carrying xenografts with forced E-cadherin (468-CDH1) than in their controls, as well as a reduced number when E-cadherin was knocked down despite the considerably longer tumor exposure time (Table 4).