Danshensu, another TCM, which is a water-extractable component of the medicinal herb Salvia miltiorrhiza, protects the endothelium in rats with hyperhomocysteinemia by modulating the abnormality in the parameters such as NO, ET-1, and other inflammatory markers induced by hyperhomocysteinemia [66]; homocysteine is a byproduct of numerous biological processes in the human body and, when elevated, it may be associated with severe atherosclerosis and thrombotic occlusions [67]. This evidence concerns the gene EDN1 and hyperhomocysteinemia.