INS and Insulin resistance: Several mechanisms underlie FFA-induced insulin resistance such as intracellular accumulation of triglycerides (TG) and diacylglycerol (DAG), activation of serine/threonine kinases, reduced tyrosine phosphorylation of the insulin receptor substrate 1/2 (IRS 1/2) and impairment of the IRS/phosphoinositol 3 kinase (PI3K) pathway, involved in insulin signaling [3, 80].