On multivariate analysis, overweight/obese at study entry (OR 2.723, 95% CI 1.568–4.728, p = 0.0004) and estrogen receptor positivity (OR 0.552, 95% CI 0.311–0.980, p = 0.0423) were independent factors for hypertension. The gene discussed is ESR1; the disease is hypertensive disorder.