Knowing that the endocannabinoid system is hyperactivated in the obesity stage[35] and due to our previous study, where we showed that CB1R induces expression of ERRγ and its effect on modulating hepatic bile acid metabolism by alcohol [30], we speculated that CB1R might also involve in regulating fibrinogen expression in liver. This evidence concerns the gene ESRRG and obesity due to melanocortin 4 receptor deficiency.