CNR1 and hepatocellular carcinoma: In this study, our results show for the first time that activation of hepatic CB1R can induce fibrinogen expression via ERRγ in human hepatoma cell lines, and that knockdown ERRγ by Ad-shERRγ or the inverse agonist GSK5182 can inhibit ACEA-mediated induction of fibrinogen gene expression (Fig 4).