Both channels are implicated in Brugada syndrome (BRGDA1, OMIM: 601144; BRGDA9, OMIM: 616399), and consequently a DLG1 variant may confer susceptibility to arrhythmias as demonstrated by a putative DLG1 pathogenic mutation in a patient affected by this syndrome [84]. Here, DLG1 is linked to Brugada syndrome.