We have previously shown that Jag1 and NICD1 protein levels did not decrease before 16-24hpi (S1 Fig) [5], which was after Hes1 downregulation started (12hpi), indicating the Hes1 downregulation is not a consequence of Jag1 and NICD1 dysregulation in the IE phase of infection. The gene discussed is JAG1; the disease is infection.