RIGI and infection: As shown in Fig 7A, the levels of tyrosine-phosphorylated STAT1 and RIG-I were lower at 24, 48 and 72 h post-infection with either the CA/04-NAK331N or CA/04-NAS79L,K331N viruses compared to infection with the parental CA/04 strain or the CA/04-NAS79L viruses.