Moreover, most centres who routinely screen for genetic AID only offer screening of common disease harbouring exons of a minority of the known AID genes, including in the UK, where screening for 6 diseases is currently routinely available: Cryopyrin-Associated Periodic Syndromes (CAPS), Mevalonate Kinase Deficiency (MKD) also known as Hyper IgD Syndrome (HIDS), Tumour Necrosis Factor-(TNF) Receptor Associated Periodic Fever Syndrome (TRAPS), Familial Mediterranean Fever (FMF), Familial Cold Autoinflammatory Syndrome 2 (FCAS2), Blau’s syndrome; and for the hereditary amyloidoses. Here, AICDA is linked to familial cold autoinflammatory syndrome 2.