Clinicians can also design panels targeting genes of interest to suit their own clinical practice: as well as AID genes, we included a range of immunodeficiency genes in VIP since we were increasingly aware that autoinflammation could be a feature of primary immunodeficiency [13]; and important genetic mimics of vasculitis (congenital vasculopathies). The gene discussed is AICDA; the disease is Immunodeficiency.