CRHR1 and Alzheimer disease: With chronic treatment of CRFR1 antagonist (R121919) in the preclinical phase of AD, levels of H2O2 and 8-OHdG are significantly reduced in urine of Tg mice, indicating that R121919 may attenuate oxidative stress by decreasing glucocorticoid in the HPA axis, thereafter, DNA oxidation can be prevented by drug treatment.