MECOM is a transcription factor with no clear downstream targets and with no transcription profile been reported before, therefore more in-depth research on the relationship of FGF9 and MECOM biological functions could lead to the discovery of potential irinotecan targets, which can hasten a new chemical drug therapy for metastatic CRC which will improve the survival time and life quality of CRC patients therefore increasing the significance of FGF9 and MECOM in irinotecan treatment in CRC. The gene discussed is FGF9; the disease is colorectal carcinoma.