For example, in TCGA head and neck cancer, we observed relationships between CD8+ T cell estimates and mutations in the p53 tumor suppressor (TP53, Chr17), caspase 8 (CASP8, Chr2) the RNA polymerase component POLR3A (Chr10), death-inducer obliterator 1 (DIDO1 Chr20), and CYLD (Chr16), a modulator of the nuclear factor kappa-B pathway (Fig 2). The gene discussed is POLR3A; the disease is head and neck cancer.