Finally, amplification of PD-L1 (CD274) on chromosome 9p by neoplasms is well documented in Hodgkin lymphoma; one might hypothesize that, considering its known immuno-suppressive role, amplification of the PD-L1 genomic region could be an active immuno-evasion mechanism in multiple tumor types[27]. This evidence concerns the gene CD274 and Hodgkins lymphoma.