APC and liver cancer: No significant association of beta-catenin (CTNNB1) mutations with estimates of immune levels was observed in our study, although there was a negative association between mutation and markers of fibroblast content in liver cancer (data not shown) Mutations of APC, a tumor suppressor in the WNT/beta-catenin pathway, were linked to lower levels of monocyte, macrophage, and CD8+ T cell estimates in colon adenocarcinoma and higher NK cell estimates in kidney papillary cell cancer (Table 4).