Although amplification of MYC is inversely correlated with T cell estimates in some tumor types and Spranger et al. report a strong relationship between MYC expression and T cell estimates in melanoma[13], once we included estimates of tumor purity as a covariate in the analysis we did not observe association of MYC CNA with immune estimates in melanoma, and limited association elsewhere. The gene discussed is MYC; the disease is neoplasm.