Indicative of intravascular hemolysis, haptoglobin was rapidly depleted in G6PD-heterozygous subjects with values ≤ 0.25 μg/dL in 3/3 subjects in the tafenoquine 300 mg group and 3/5 in the primaquine group, before recovery started at around day 9 (Figure 4, Table 2). This evidence concerns the gene HP and hemolysis.