They indicate that genetic insults contributing to this pathophysiology occur not only in pathways commonly linked to FTD (e.g., TDP-43, progranulin), but also in a wide variety of other pathways, e.g., mitochondrial (CHCHD10), amyloid (PSEN1, PSEN2), lipofuscinosis (CTSF), and cholesterol homeostasis (CYP27A1) pathways. Here, PSEN2 is linked to frontotemporal dementia.