To confirm that miR-181d promotes CRC growth and metastasis by enhancing c-myc-mediated glycolysis, we compared the effects of anti-miR-181d, 10058-F4, and FX11 (a lactate dehydrogenase A (LDHA, which executives the final step of Warburg effect by converting the pyruvate to lactate) inhibitor) on CRC cells.17 LDHA executives the final step of Warburg effect by converting the pyruvate to lactate.17 As shown in Figure 5a, anti-miR-181d, or 10058-F4, or FX11 significantly inhibited lactate content, while c-myc transfection rescued the phenotype of anti-miR-181d in CRC cells. This evidence concerns the gene LDHA and colorectal carcinoma.