WWOX and ovarian carcinoma: We examined the the levels of transforming growth factor-β1 (TGFB1), which has previously been shown to be a critical mediator of paclitaxel response in ovarian cancer.24 We could not detect measurable levels of secreted TFGB1 in culture medium in PEO1 clones, but quantitative RT-PCR (QPCR) revealed variable TGFBI levels and no correlation with WWOX expression (Figure 3e).