TP53 and squamous cell carcinoma: WWOX sensitises squamous cell carcinoma cells to apoptosis induced by the antifolate chemotherapeutic agent methotrexate by regulating autophagy responses in cancer cells and absence of WWOX leads to chemotherapeutic drug resistance.33 A second study demonstrated that WWOX through its WW1 domain interacts with the p53 homologue protein ΔNP63 known to induce chemoresistance in cancer cells.