New evidence supports a key autophagy-independent role for the adaptor SQSTM1 in the signaling functions central to tumor initiation in the epithelium and suppression of tumor progression in the stroma.39 Schläfli et al.40 reported the autophagy markers LC3 and SQSTM1 had prognostic value in early-stage non-small cell lung cancer. The gene discussed is MAP1LC3A; the disease is non-small cell lung carcinoma.