The role of keratins as multifunctional regulators of epithelial tumorigenesis merits further exploration.12 KRT23 transcripts were highly induced in AsPC-1 cells (a human pancreatic cancer cell line) following treatment with a histone deacetylase inhibitor,13 and KRT23 is considered a tumor-associated serum antigen in patients with hepatocellular carcinoma.14 This evidence concerns the gene KRT23 and familial pancreatic carcinoma.