To confirm these findings, protein levels of KLF5 were detected by immunohistochemistry (IHC) in clinical ccRCC tumors and adjacent normal tissues from Ren-Ji Hospital affiliated to Shanghai Jiao Tong University School of Medicine, and the related clinical information of these patients were shown (Supplementary Table 1). The gene discussed is KLF5; the disease is nonpapillary renal cell carcinoma.