DNMT2 is shown to methylate RNA and DNMT3L does not have methyltransferase activity.8 Previous studies have showed hypermethylation of KLF5 in intron 1 that downregulated KLF5 expression might correlated with DNMT3A mutation in AML.21, 33, 34 In this study, we found that KLF5 expression was also suppressed by hypermethylation, but the methylated loci reported in AML, including that in proximal promoter (−529 to −318 bp from transcription start site (TSS)) and in intron 1 (+1284 to +1571 bp from TSS), could not be found in ccRCC. Here, DNMT3L is linked to acute myeloid leukemia.