Since hypermethylation of KLF5 suppressed its expression and ectopic KLF5 could inhibit ccRCC growth both in vitro and in vivo, it is very interesting to evaluate whether upregulating endogenous KLF5 expression by demethylation of KLF5 gene could inhibit cell growth. Here, KLF5 is linked to nonpapillary renal cell carcinoma.