KCNH2 and heart failure: The KCNE1-c.G112A (p.G38S) variant has been reported to reduce KCNH2 and KCNQ1 channel currents, enhance KCNH2 susceptibility to QT-prolonging factors, and increase the risk for LQTS, atrial fibrillation, and heart failure [24,25,26,27,28].