KCNH2 and familial long QT syndrome: Moreover, given the complex association of LQTS mutants in the individuals of the family and the potential causative role of each mutation, and also based on in silico analysis and on evidence from previous studies, we focused on the in vitro functional characterization of the KCNQ1-p.R583H and KCNH2-p.C108Y variants [9,18,19,20,21,22,23,24,25,26,27,28].