Moreover, the MAF of KCNQ1-p.R583H was much smaller (0.000016) than the estimated prevalence of LQTS (0.0005), whereas the MAFs of KCNH2-p.K897T and KCNE1-p.G38S were much larger (0.187 and 0.352, respectively). This evidence concerns the gene KCNQ1 and familial long QT syndrome.