In the present study, we successfully confirmed the protective effects of AC on AD, as suggested by the improvement in cell viability, reduction in the proportion of apoptotic cells, restoration of MMP dissipation, inhibition of ROS and Ca2+ overproduction, regulation of the expression of apoptosis-related proteins, influence of Akt/mTOR signal pathway in l-Glu-damaged HT22 cells, and the enhancement of learning and memory abilities in experimental AD mice associated with the regulation of oxidative stress and the cholinergic system. This evidence concerns the gene AKT1 and Alzheimer disease.