SOD1 and Alzheimer disease: In AD experimental mice, however, a 24.6% reduction in SOD and a 44.7% increase in ROS in the brain were noted (p < 0.01; Figure 5), but a 28-day AC administration enhanced SOD levels (p < 0.05; Figure 5A) and reduced ROS levels (p < 0.05; Figure 5B) in the brain.