Using a comprehensive metabolomics analysis with isogenic CRC cell lines harboring mutated or wild-type KRAS, we have recently reported that mutated KRAS induces some metabolic alterations in glycolysis, the pentose phosphate pathway (PPP), the tricarboxylic acid (TCA) cycle, and most significantly in the amino acid pathway [12]. The gene discussed is KRAS; the disease is colorectal carcinoma.