However, myopathy seen in global H6PDH deficiency is glucocorticoid and 11β‐HSD1 independent, but it was unknown whether loss of H6PDH in nonskeletal muscle tissue contributed to myopathy.17 Having now generated and validated H6MKO mice, we can confirm phenocopy of the myopathy seen in global H6PD KO mice and conclude that the phenotype originates in muscle and is not influenced by other tissues. Here, H6PD is linked to myopathy.