OGDH is downregulated in colorectal cancer as the result of promoter hypermethylation and similar promoter hypermethylation has been documented in breast, lung, esophageal, cervical, and pancreatic cancer (Hoque et al., 2008; Ostrow et al., 2009; Fedorova et al., 2015). The gene discussed is OGDH; the disease is colorectal cancer.